1.
J Inorg Biochem
; 228: 111691, 2022 03.
Article
in English
| MEDLINE | ID: covidwho-1558451
ABSTRACT
Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. This evidence justifies the efforts in applying Zinc ionophores to restore Zinc homeostasis and treat bacterial/viral infections such as coronavirus diseases. Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. This review provides, for the first time, an overview of the applications of the main Zinc ionophores in Zinc deficiency, infectious diseases, and in cancer, discussing the pharmacological and coordination properties of the Zinc ionophores.
Subject(s)
Communicable Diseases/drug therapy , Ionophores/chemistry , Neoplasms/drug therapy , Zinc/chemistry , Zinc/pharmacology , Acrodermatitis/drug therapy , Anti-Bacterial Agents/pharmacology , Antineoplastic Agents/pharmacology , Antiviral Agents/pharmacology , Homeostasis/drug effects , Humans , Ionophores/pharmacology , Zinc/deficiency , COVID-19 Drug Treatment
2.
Acta Derm Venereol
; 101(2): adv00399, 2021 02 16.
Article
in English
| MEDLINE | ID: covidwho-1069707
3.
Dermatol Ther
; 33(4): e13787, 2020 Jul.
Article
in English
| MEDLINE | ID: covidwho-767359